5 edition of Osteopontin found in the catalog.
by New York Academy of Sciences
Written in English
|The Physical Object|
|Number of Pages||388|
Osteopontin (OPN) is a bone matrix derivative, whose levels reflect active lesions of aggravated periodontal disease accompanied by alveolar bone is also a component of human atherosclerotic plaque, whose levels are also found to commensurate with the progression of periodontal disease in Gingval Crevicular Fluid and Blood : Suruchi Hans, Amita Mali, Rachna M. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies. UniProt ID: P (mouse), P (rat) Regulatory Status: RUO - Research Use Only.
The present invention relates to a method for assessing colorectal cancer (CRC) in vitro comprising measuring in a sample the concentration and/or activity of a seprase polypeptide and/or fragments thereof and of either anti-p53 and/or osteopontin and/or Ferritin, of optionally one or more other marker of CRC, and using the combined measurement result in the assessment of CRC. Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus Authors: C Wang, M He, J Peng, S Li, M Long, W Chen, D Liu, G Yang, L Zhang Cytokine, ;(0) Species: Human Sample Types: Plasma; Blood serum proteins as biomarkers for prediction of survival, locoregional control and distant metastasis rate in.
Recently the molecule osteopontin has been implicated in several types of liver disease and could be a potential biomarker and therapeutic target to treat liver fibrosis. Many authors demonstrated that this molecule correlate with the degree of . Osteopontin is also called Eta-1 (early T lymphocyte activation factor 1) because it is a ligand of CD44 and plays a role in cell-mediated immunity. Its deficiency severely impairs the immunity of mice to Herpes simplex virus 1 and bacterial (Listeria monocytogenes) infection.
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Verma, D.S. Krause, in Advances in Stem Cells and their Niches, Osteopontin. Osteopontin is an extracellular matrix protein found in the BMM, where it is produced by osteoblastic and mesenchymal stem cells.
The number of hematopoietic stem and progenitor cells (HSPC) in an osteopontin-deficient BMM was increased, suggesting that osteopontin negatively regulates HSC.
Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).Aliases: SPP1, BNSP, BSPI, ETA-1, OPN.
Osteopontin is a member of the recently classified SIBLING (Small Integrin Binding LIgand N-linked Glycoprotein) family of proteins that have been shown to bind to and regulate the activity of MMPs . Osteopontin binds to recombinant proMMP-3 and active MMP In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature.
OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). It Cited by: 1.
Introduction. Osteopontin (OPN; encoded by the gene secreted phosphoprotein 1, SPP1) is a multifunctional matricellular glycoprotein secreted by a variety of activated immune cells such as macrophages and T cells, among other cell types (Franzen and Heinegard,Patarca et al.,Scatena et al., ).It is highly expressed by bone marrow (BM)-derived myelomonocytic cells and Cited by: Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised bone matrix, as well as being a bone matrix protein.
Osteopontin (OPN) is Osteopontin book of the noncollagenous proteins present in bone matrix. The presence of OPN in various organs, including those with and without matrix, and also in plasma, suggests that this molecule could act both as a structural molecule and as a humoral factor, or cytokine.
Osteopontin Antibodies. Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors.
It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and. Osteopontin (OPN) is the pro-inflammatory cytokine reported to be associated with synovitis in RA, as it generates T-helper-1 (T H 1)-mediated cellular immune response.
Objective To study the impact of MTHFR gene polymorphism on the serum levels of OPN in RA patients and to investigate the cause of greater disease severity in women than men.
Osteopontin/OPN: Products. Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed. Osteopontin (OPN) is a multifaceted matricellular protein, with well-recognized roles in both the physiological and pathological processes in the body.
OPN is expressed in the main organs and cell types, in which it induces different biological actions. During physiological conditioning, OPN acts as both an intracellular protein and soluble excreted cytokine, regulating tissue remodeling and.
Role of osteopontin in immune cell regulation in the tumor microenvironment. Osteopontin (OPN, encoded by SPP1) is a multifunctional phosphoglycoprotein produced by various cells, including T, B, NK, and NKT lymphocytes, myeloid cells, osteoblasts, osteocytes, epithelial cells, and OPN expression is detected in bone, joints, adipose tissue, liver, lung, brain, and.
Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer.
Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Osteopontin," including when used in literature (e.g.
all authors that might have Osteopontin in their name).Price: $ Osteopontin Antibody is a Mouse monoclonal antibody for cancer research against Osteopontin.
Mouse Monoclonal, Size: 1 mg. More sizes available, please contact us on [email protected] for details. Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. OPN is synthesized in a variety of cells and tissues.
It can be found not only in bone cells but also in immune cells (B and T lymphocytes, natural killer (NK) cells, natural killer T (NKT) cells, macrophages, neutrophils, and dendritic cells).
OPN regulates T-helper 1/T-helper 2 (Th1/Th2. In an article published in the prestigious journal Aging Cell, the UPV/EHU's Lipids & Liver research group shows that contrary to expectations, physiological levels in the liver of osteopontin, a.
Osteopontin: Role in Cell Signalling and Adhesion (Annals of the New York Academy of Sciences) by William T. Butler (Author), David T.
Denhardt (Editor), Ann F. Chambers (Editor) & ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or. Human milk contains several bioactive proteins, including lactoferrin (LF) and osteopontin (OPN).
These two proteins have been shown to form a complex, which shows increased bioactivities. Bovine LF and OPN can also form such a complex. We assessed bioactivities of the bovine LF–OPN complex (at molar ratios of LF:OPN =, or ) in a formula protein matrix, including LF, OPN, bovine.
The Osteopontin/OPN Antibody (1B20) from Novus Biologicals is a mouse monoclonal antibody to Osteopontin/OPN. This antibody reacts with human, rat, rabbit.
View protein in InterPro IPR, Osteopontin IPR, Osteopontin_CS: PANTHER i: PTHR, PTHR, 2 hits: Pfam i: View protein in Pfam PF, Osteopontin, 1 hit PRINTS i: PR, OSTEOPONTIN: SMART i: View protein in SMART SM, OSTEO, 1 hit: PROSITE i: View protein in PROSITE PSA negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological | Explore the latest full-text research PDFs, articles.
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.